The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

The glyoxalase system is a ubiquitous enzymatic network which plays important roles in
biological life. It consists of glyoxalase 1 (GLO1), glyoxalase 2 (GLO2), and reduced …

This protocol describes a method for the detection and quantification of methylglyoxal (MG),
the major physiological substrate of the cytosolic glyoxalase system. Accumulation of MG …

OBJECTIVE—Diabetes is characterized by marked postprandial endothelial dysfunction
induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs) …

Glycation is a spontaneous age‐dependent posttranslational modification that can impact
the structure and function of several proteins. Interestingly, glycation can be detected at the …

Aging is a multifactorial process that involves changes at the cellular, tissue, organ and the
whole body levels resulting in decreased functioning, development of diseases, and …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …

Diabetes increases the percentage of circulating erythrocytes exposing phosphatidylserine
(PS) at the cell surface. PS-exposing erythrocytes are recognized, bound, engulfed and …