[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Part 10: special circumstances of resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular …
EJ Lavonas, IR Drennan, A Gabrielli, AC Heffner… - Circulation, 2015 - Am Heart Assoc
Guidelines Update for Cardiopulmonary Resuscitation (CPR) and Emergency
Cardiovascular Care (ECC) addresses cardiac arrest in situations that require special …
Cardiovascular Care (ECC) addresses cardiac arrest in situations that require special …
Chiral toxicology: it's the same thing… only different
SW Smith - Toxicological sciences, 2009 - academic.oup.com
Chiral substances possess a unique architecture such that, despite sharing identical
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …
Drug-induced long QT syndrome
The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …
Opioid-associated out-of-hospital cardiac arrest: distinctive clinical features and implications for health care and public responses: a scientific statement from the …
Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …
liver. Expression is highly variable both between individuals and within individuals, owing to …
[图书][B] Karch's pathology of drug abuse
SB Karch, O Drummer - 2008 - taylorfrancis.com
Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …
information focused on the investigation of drug-related deaths and practical approaches to …
QTc interval screening in methadone treatment
MJ Krantz, J Martin, B Stimmel, D Mehta… - Annals of internal …, 2009 - acpjournals.org
Description: An independent panel developed cardiac safety recommendations for
physicians prescribing methadone. Methods: Expert panel members reviewed and …
physicians prescribing methadone. Methods: Expert panel members reviewed and …
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
H Wang, LM Tompkins - Current drug metabolism, 2008 - ingentaconnect.com
Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …