[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Part 10: special circumstances of resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular …

EJ Lavonas, IR Drennan, A Gabrielli, AC Heffner… - Circulation, 2015 - Am Heart Assoc
Guidelines Update for Cardiopulmonary Resuscitation (CPR) and Emergency
Cardiovascular Care (ECC) addresses cardiac arrest in situations that require special …

Chiral toxicology: it's the same thing… only different

SW Smith - Toxicological sciences, 2009 - academic.oup.com
Chiral substances possess a unique architecture such that, despite sharing identical
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …

Drug-induced long QT syndrome

P Kannankeril, DM Roden, D Darbar - Pharmacological reviews, 2010 - ASPET
The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

UM Zanger, M Turpeinen, K Klein… - Analytical and bioanalytical …, 2008 - Springer
We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …

Opioid-associated out-of-hospital cardiac arrest: distinctive clinical features and implications for health care and public responses: a scientific statement from the …

C Dezfulian, AM Orkin, BA Maron, J Elmer, S Girotra… - Circulation, 2021 - Am Heart Assoc
Opioid overdose is the leading cause of death for Americans 25 to 64 years of age, and
opioid use disorder affects> 2 million Americans. The epidemiology of opioid-associated out …

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

UM Zanger, K Klein - Frontiers in genetics, 2013 - frontiersin.org
Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …

[图书][B] Karch's pathology of drug abuse

SB Karch, O Drummer - 2008 - taylorfrancis.com
Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

QTc interval screening in methadone treatment

MJ Krantz, J Martin, B Stimmel, D Mehta… - Annals of internal …, 2009 - acpjournals.org
Description: An independent panel developed cardiac safety recommendations for
physicians prescribing methadone. Methods: Expert panel members reviewed and …

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme

H Wang, LM Tompkins - Current drug metabolism, 2008 - ingentaconnect.com
Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic
cytochrome P450 (CYP) content and to have a minor function in human drug metabolism …