ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that
protects cells. These peptides share common structural and physicochemical properties and …

First designed and published in 1998 as a laboratory tool to study Myc perturbation,
Omomyc has come a long way in the past 22 years. This dominant negative has contributed …

Cell-penetrating peptides (CPPs) have been used in basic and preclinical research in the
past 30 years to facilitate drug delivery into target cells. However, translation toward the …

Bacterial infections caused by intracellular pathogens are difficult to control. Conventional
antibiotic therapies are often ineffective, as high doses are needed to increase the number …

In molecular cancer therapeutics only 10% of known cancer gene products are targetable
with current pharmacological agents. Major oncogenic drivers, such as MYC and KRAS …

Proteins have the capacity to treat a multitude of diseases both as therapeutics and as drug
carriers due to their complex functional properties, specificity toward binding partners …

The translational therapies to promote interaction between cell and signal come with
stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet …

Cancer comprises a heterogeneous disease, characterized by diverse features such as
constitutive expression of oncogenes and/or downregulation of tumor suppressor genes …