Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

Acute lymphoid leukemia (ALL) is a type of hematological neoplasm that affects the
precursor cells of strains B, T and NK, with a higher incidence in the pediatric range. The …

Metastasis of breast and prostate cancer as well as multiple myeloma to the bones
represents a significant medical problem. We herein discuss the molecular basis of the …

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …

Bone marrow-derived mesenchymal stem cells (BMSCs) are of specific attention due to their
potential clinical use in cell transplantation. These cells could secrete cytokines and growth …

The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic
malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) …

Metastasis is a multistep process, which refers to the ability to leave a primary tumor through
circulation toward the distant tissue and form a secondary tumor. Bone is a common site of …

Backgrounds Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in
adults and is characterized by a clonal accumulation of mature apoptosis-resistant …

Background Acute leukemia is currently the major cause of death in hematological
malignancies. Despite the rapid development of new therapies, minimal residual disease …

Leukemia stem cells utilize cell adhesion molecules like CXCR4/CXCL12 to home to bone
marrow stromal niches where they are maintained in a dormant, protected state. Dociparstat …