Chromosomal changes: induction, detection methods and applicability in human biomonitoring

R Mateuca, N Lombaert, PV Aka, I Decordier… - Biochimie, 2006 - Elsevier
The objective of this state of the art paper is to review the mechanisms of induction, the fate,
the methodology, the sensitivity/specificity and predictivity of two major cytogenetic …

The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance

M Kirsch-Volders, G Plas, A Elhajouji… - Archives of …, 2011 - Springer
Micronuclei (MN) are small, extranuclear bodies that arise in dividing cells from acentric
chromosome/chromatid fragments or whole chromosomes/chromatids lagging behind in …

Children's exposure to environmental pollutants and biomarkers of genetic damage: II. Results of a comprehensive literature search and meta-analysis

M Neri, D Ugolini, S Bonassi, A Fucic, N Holland… - … Research/Reviews in …, 2006 - Elsevier
The present review is based on findings from 178 publications retrieved through an
extensive search of the MedLine/PubMed database for a 25 years time period (1980–2004) …

Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring

I Decordier, A Papine, G Plas, S Roesems… - …, 2008 - academic.oup.com
Micronuclei (MN) frequencies in peripheral blood lymphocytes have been used worldwide
as a biomarker of chromosomal damage for genotoxicity testing and biomonitoring studies …

Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease

MG Andreassi, L Ait-Ali, N Botto, S Manfredi… - European heart …, 2006 - academic.oup.com
Aims Medical radiological exposure is associated with an additional risk of cancer. Children
with repaired congenital heart disease (CHD) are theoretically at a relatively greater cancer …

Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the γ‐H2AX focus assay and micronucleus test

R Scarpato, C Verola, B Fabiani, V Bianchi… - The FASEB …, 2011 - Wiley Online Library
Childhood obesity, often characterized by a chronic low‐grade inflammation, has been
associated with an increased risk of developing some types of cancer later in life. Nuclear γ …

A machine learning method for improving the accuracy of radiation biodosimetry by combining data from the dicentric chromosomes and micronucleus assays

I Shuryak, E Royba, M Repin, HC Turner, G Garty… - Scientific Reports, 2022 - nature.com
A large-scale malicious or accidental radiological event can expose vast numbers of people
to ionizing radiation. The dicentric chromosome (DCA) and cytokinesis-block micronucleus …

Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables

N Holland, A Fucic, DF Merlo, R Sram… - …, 2011 - academic.oup.com
Children may be more susceptible to the effects of the environmental exposure and medical
treatments than adults; however, limited information is available about the differences in …

Automated image analysis of micronuclei by IMSTAR for biomonitoring

I Decordier, A Papine, K Vande Loock, G Plas… - …, 2011 - academic.oup.com
For many years, the analysis of micronuclei (MN) has been successfully applied to human
biomonitoring of in vivo genotoxin exposure and provides a sensitive and relatively easy …

Arsenic and lead contamination in urban soils of Villa de la Paz (Mexico) affected by historical mine wastes and its effect on children's health studied by …

SP Gamiño-Gutiérrez, CI González-Pérez… - … geochemistry and health, 2013 - Springer
Environmental geochemical and health studies were carried out in urban areas of Villa de la
Paz, SLP (Mexico), where mining activities have been developed for more of 200 years …