Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Adverse pregnancy outcomes significantly contribute to morbidity and mortality for mother
and child, with lifelong health consequences for both. The innate and adaptive immune …

It is well established that the organ damage that complicates human diabetes is caused by
prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels …

The complement system is critical to human health owing to its central role in host defense
and innate immunity. During pregnancy, the complement system must be appropriately …

The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …

Soluble defense collagens form a group of secreted proteins that are primarily involved in
host defense. All defense collagens contain a globular recognition domain contiguous to a …

Both C1q and calreticulin (CRT) are involved in the recognition of apoptotic cells. CRT was
initially characterized as a receptor for the C1q collagen-like fragment (CLF), whereas C1q …

C1q, the ligand-binding unit of the C1 complex of complement, is a pattern recognition
molecule with the unique ability to sense an amazing variety of targets, including a number …

C1q, historically viewed as the initiating component of the classical complement pathway,
also exhibits a variety of complement-independent activities in both innate and acquired …

The involvement of complement activation in the pathophysiology of antiphospholipid
syndrome (APS) was first reported in murine models of antiphospholipid antibody (aPL) …