Pharmacology of heparin and related drugs
B Mulloy, J Hogwood, E Gray, R Lever, CP Page - Pharmacological reviews, 2016 - ASPET
Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …
decades and is still widely used in clinical practice for a variety of indications. The …
The complement system and adverse pregnancy outcomes
JF Regal, JS Gilbert, RM Burwick - Molecular immunology, 2015 - Elsevier
Adverse pregnancy outcomes significantly contribute to morbidity and mortality for mother
and child, with lifelong health consequences for both. The innate and adaptive immune …
and child, with lifelong health consequences for both. The innate and adaptive immune …
Role of complement and complement regulatory proteins in the complications of diabetes
It is well established that the organ damage that complicates human diabetes is caused by
prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels …
prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels …
Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome
RM Burwick, BB Feinberg - American journal of obstetrics and gynecology, 2022 - Elsevier
The complement system is critical to human health owing to its central role in host defense
and innate immunity. During pregnancy, the complement system must be appropriately …
and innate immunity. During pregnancy, the complement system must be appropriately …
Progress and trends in complement therapeutics
D Ricklin, JD Lambris - Complement Therapeutics, 2013 - Springer
The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …
complement-directed drug discovery and development. Driven by promising experiences …
[HTML][HTML] Soluble defense collagens: Sweeping up immune threats
Soluble defense collagens form a group of secreted proteins that are primarily involved in
host defense. All defense collagens contain a globular recognition domain contiguous to a …
host defense. All defense collagens contain a globular recognition domain contiguous to a …
Investigations on the C1q–calreticulin–phosphatidylserine interactions yield new insights into apoptotic cell recognition
H Païdassi, P Tacnet-Delorme, M Verneret… - Journal of molecular …, 2011 - Elsevier
Both C1q and calreticulin (CRT) are involved in the recognition of apoptotic cells. CRT was
initially characterized as a receptor for the C1q collagen-like fragment (CLF), whereas C1q …
initially characterized as a receptor for the C1q collagen-like fragment (CLF), whereas C1q …
The human c1q globular domain: structure and recognition of non-immune self ligands
C Gaboriaud, P Frachet, NM Thielens… - Frontiers in …, 2012 - frontiersin.org
C1q, the ligand-binding unit of the C1 complex of complement, is a pattern recognition
molecule with the unique ability to sense an amazing variety of targets, including a number …
molecule with the unique ability to sense an amazing variety of targets, including a number …
Fundamental role of C1q in autoimmunity and inflammation
M Son, B Diamond, F Santiago-Schwarz - Immunologic research, 2015 - Springer
C1q, historically viewed as the initiating component of the classical complement pathway,
also exhibits a variety of complement-independent activities in both innate and acquired …
also exhibits a variety of complement-independent activities in both innate and acquired …
Complement and thrombosis in the antiphospholipid syndrome
K Oku, H Nakamura, M Kono, K Ohmura, M Kato… - Autoimmunity …, 2016 - Elsevier
The involvement of complement activation in the pathophysiology of antiphospholipid
syndrome (APS) was first reported in murine models of antiphospholipid antibody (aPL) …
syndrome (APS) was first reported in murine models of antiphospholipid antibody (aPL) …