Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

TR Steel, F Walsh, A Wieczorek-Błauż, M Hanif… - Coordination chemistry …, 2021 - Elsevier
Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome
potential toxicity and equip metal-based anticancer agents with biological activity, the choice …

Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine

I Dakilah, A Harb, E Abu-Gharbieh… - Frontiers in …, 2024 - frontiersin.org
The global burden of cancer continues to rise, underscoring the urgency of developing more
effective and precisely targeted therapies. This comprehensive review explores the …

Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models

R Wei, L Mao, P Xu, X Zheng, RM Hackman… - Food & function, 2018 - pubs.rsc.org
Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol
in green tea, has anti-cancer properties. However, its mechanism of action in breast cancer …

PD-1+ mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy

J Li, G Peng, K Zhu, X Jie, Y Xu, X Rao, Y Xu… - Cancer Immunology …, 2023 - Springer
Background Programmed cell death protein 1 (PD-1) antibody has been approved for a
variety of tumors, but its effective rate is unsatisfactory. New evidence suggests that mast …

[PDF][PDF] Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12 CirVir)

N Ganne‐Carrié, R Layese, V Bourcier, C Cagnot… - …, 2016 - Wiley Online Library
The aim of this work was to develop an individualized score for predicting hepatocellular
carcinoma (HCC) in patients with hepatitis C (HCV)‐compensated cirrhosis. Among 1,323 …

[PDF][PDF] Inhibition of mast cell‐secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2−/− mice

H Jones, L Hargrove, L Kennedy, F Meng… - …, 2016 - Wiley Online Library
Hepatic fibrosis is marked by activation of hepatic stellate cells (HSCs). Cholestatic injury
precedes liver fibrosis, and cholangiocytes interact with HSCs promoting fibrosis. Mast cells …

[HTML][HTML] Hyaluronic acid (HA)-coated naproxen-nanoparticles selectively target breast cancer stem cells through COX-independent pathways

E Espinosa-Cano, M Huerta-Madronal… - Materials Science and …, 2021 - Elsevier
Cytotoxic chemotherapy continues to be the main therapeutic option for patients with
metastatic breast cancer. Several studies have reported a significant association between …

[HTML][HTML] Mast cell-T cell axis alters development of colitis-dependent and colitis-independent colorectal tumours: potential for therapeutically targeting via mast cell …

JY Sakita, J Elias-Oliveira, D Carlos… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Colorectal cancer (CRC) has a high mortality rate and can develop in either
colitis-dependent (colitis-associated (CA)-CRC) or colitis-independent (sporadic (s) CRC) …

Reduction-responsive polypeptide nanogel delivers antitumor drug for improved efficacy and safety

K Huang, B Shi, W Xu, J Ding, Y Yang, H Liu… - Acta Biomaterialia, 2015 - Elsevier
Chemotherapy plays an irreplaceable role in the treatment of various malignant tumors
today. The traditional drug formulations lack of selectivity, cause serious damage to normal …

Secondary Metabolites Profiling, Antimicrobial and Cytotoxic Properties of Commiphora gileadensis L. Leaves, Seeds, Callus, and Cell Suspension Extracts

AM Al-Abdallat, BK Adayileh, JS Sawwan, R Shibli… - Metabolites, 2023 - mdpi.com
Commiphora gileadensis L. is an important endangered medicinal plant that belongs to the
family Burseraceae. In this study, C. gileadensis callus culture was established successfully …