Methods from artificial intelligence (AI) trained on large datasets of sequences and
structures can now" write" proteins with new shapes and molecular functions de novo …

Developmental biology has greatly profited from genetic and reverse genetic approaches to
indirectly studying protein function. More recently, nanobodies and other protein binders …

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the
pivotal contributors to the acute inflammatory response. Initially, neutrophils were …

Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of
postmitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is …

The phenomenal diversity of neuronal types in the central nervous system is achieved in
part by the asymmetric division of neural precursors. In zebrafish neural precursors …

Apicobasal epithelial polarity controls the functional properties of most organs. Thus, there
has been extensive research on the molecular intricacies governing the establishment and …

As a fundamental process governing the self-renewal and differentiation of stem cells,
asymmetric cell division is controlled by several conserved regulators, including the polarity …

This review describes in detail the morphological, cytoskeletal and gene expression events
leading to the gene regulatory network bifurcation point of trophoblast and inner cell mass …

Tissue patterning, the process of localizing different cell types to the right place, is critical for
tissue function and thus a central goal for tissue engineering. Developing embryos employ …

The Par3 polarity protein is critical for subcellular compartmentalization in different
developmental processes. Variants of PARD3, encoding PAR3, are associated with …