Dosing time accounts for a large variability in efficacy and/or toxicity for many drugs.
Therefore, chronotherapy has been shown to effectively improve drug efficacy and to reduce …

The importance of drug dosing time in pharmacokinetics, pharmacodynamics, and toxicity is
receiving increasing attention from the scientific community. In spite of mounting evidence …

Abstract Δ9-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is
responsible for the drug's reinforcing effects. Retrospective human studies suggest that …

Recent estimates suggest increased popularity of the concurrent use of opioids and
stimulants, with over 50% of treatment-seeking opioid users reporting regular stimulant use …

Metabolism and transport of many drugs oscillate with times of the day (solar time), resulting
in circadian time-dependent drug exposure and pharmacokinetics. Time-dependent …

Circadian clock is known to modulate phase I metabolism, however whether and how the
phase II enzymes UDP-glucuronosyltransferases (UGTs) are regulated by circadian clock …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Traditionally, bioanalytical laboratories do not report actual concentrations for samples with
results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method …

Opioids are commonly prescribed for clinical pain management; however, dose-escalation,
tolerance, dependence, and addiction limit their usability for long-term chronic pain. The …

The importance of circadian rhythm dysfunctions in the pathophysiology of neurological
diseases has been highlighted recently. Chronopharmacology principles imply that tailoring …