Kinome-wide RNAi screen in Caenorhabditis elegans reveals new modulators of insulin signaling and longevity

M Chamoli, A Foulger, P Singh, G Lithgow… - bioRxiv, 2024 - biorxiv.org
The insulin/IGF-I-like signaling (IIS) pathway is a highly conserved signaling cascade that
plays a crucial role in regulating longevity across species. Given its significance in aging …

Patterning, regulation, and role of FoxO/DAF-16 in the early embryo

MS Mauro, SL Martin, J Dumont, M Shirasu-Hiza… - bioRxiv, 2024 - biorxiv.org
Insulin resistance and diabetes are associated with many health issues including higher
rates of birth defects and miscarriage during pregnancy. Because insulin resistance and …