Sepsis is systemic inflammatory response syndrome with a life-threatening organ
dysfunction that is caused by an unbalanced host immune response in an attempt to …

The ocular tissue microenvironment is immune-privileged and uses multiple
immunosuppressive mechanisms to prevent the induction of inflammation. The retinal …

Mitochondrial dysfunction is a key driver of inflammatory responses in human disease.
However, it remains unclear whether alterations in mitochondria-innate immune cross-talk …

Background Gut integrity is compromised in abdominal sepsis with increased cellular
apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. 1 These dysregulated host responses underpin the clinical …

Objectives: Epigenetic alterations are an important regulator of gene expression in health
and disease; however, epigenetic data in sepsis are lacking. To demonstrate proof of …

Abstract Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is
associated with various inflammatory diseases including systemic lupus erythematosus …

Systemic inflammatory responses often result in sepsis and inhibition of inflammation is one
strategy for sepsis treatment. In this study, we designed and synthesized 32 novel …

Cardiac dysfunction is a well-recognized complication of sepsis and is associated with the
outcome and prognosis of septic patients. Evidence suggests that Il12a participates in the …

Stimulator of interferons genes (STING) is an adaptor protein that plays a critical role in the
secretion of type I interferons and pro‐inflammatory cytokines in response to cytosolic …