Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
F Collin, S Karkare, A Maxwell - Applied microbiology and biotechnology, 2011 - Springer
DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at
the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher …
the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher …
The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery
With the rise of multi-drug resistant pathogens and the decline in number of potential new
antibiotics in development there is a fervent need to reinvigorate the natural products …
antibiotics in development there is a fervent need to reinvigorate the natural products …
The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae
Abstract Background The Xanthomonadaceae family contains two xylem-limited plant
pathogenic bacterial species, Xanthomonas albilineans and Xylella fastidiosa. X. fastidiosa …
pathogenic bacterial species, Xanthomonas albilineans and Xylella fastidiosa. X. fastidiosa …
[HTML][HTML] Draft genome sequences of Xanthomonas sacchari and two banana-associated xanthomonads reveal insights into the Xanthomonas group 1 clade
DJ Studholme, A Wasukira, K Paszkiewicz, V Aritua… - Genes, 2011 - mdpi.com
Genes | Free Full-Text | Draft Genome Sequences of Xanthomonas sacchari and Two
Banana-Associated Xanthomonads Reveal Insights into the Xanthomonas Group 1 Clade …
Banana-Associated Xanthomonads Reveal Insights into the Xanthomonas Group 1 Clade …
Functional interactions between gyrase subunits are optimized in a species-specific manner
D Weidlich, D Klostermeier - Journal of Biological Chemistry, 2020 - ASBMB
DNA gyrase is a bacterial DNA topoisomerase that catalyzes ATP-dependent negative DNA
supercoiling and DNA decatenation. The enzyme is a heterotetramer comprising two GyrA …
supercoiling and DNA decatenation. The enzyme is a heterotetramer comprising two GyrA …
Synthesis and antimicrobial activity of albicidin derivatives with variations of the central cyanoalanine building block
S Grätz, D Kerwat, J Kretz, L von Eckardstein… - …, 2016 - Wiley Online Library
To investigate the pharmacophore regions of the antibiotic albicidin, derivatives with
variations on the central amino acid were synthesized. Charged as well as uncharged …
variations on the central amino acid were synthesized. Charged as well as uncharged …
Pentapeptide-repeat proteins that act as topoisomerase poison resistance factors have a common dimer interface
MW Vetting, SS Hegde, Y Zhang… - … Section F: Structural …, 2011 - journals.iucr.org
The protein AlbG is a self-resistance factor against albicidin, a nonribosomally encoded
hybrid polyketide-peptide with antibiotic and phytotoxic properties produced by …
hybrid polyketide-peptide with antibiotic and phytotoxic properties produced by …
Albicidin, a potent DNA gyrase inhibitor with clinical potential
SM Hashimi - The Journal of antibiotics, 2019 - nature.com
The emergence of multiple antibiotic-resistant bacteria is a serious global problem which
requires the development of new effective antimicrobial therapeutics. Albicidin produced by …
requires the development of new effective antimicrobial therapeutics. Albicidin produced by …
Antimicrobial Susceptibility and Genomic Analysis of Aliarcobacter cibarius and Aliarcobacter thereius, Two Rarely Detected Aliarcobacter Species
I Hänel, E Müller, BG Santamarina… - Frontiers in cellular …, 2021 - frontiersin.org
Aliarcobacter cibarius and Aliarcobacter thereius are two rarely detected Aliarcobacter
species. In the study, we analyzed the antimicrobial susceptibility and provide detailed …
species. In the study, we analyzed the antimicrobial susceptibility and provide detailed …