The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

G Hoxhaj, BD Manning - Nature Reviews Cancer, 2020 - nature.com
The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

A Chadt, H Al-Hasani - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

The pathophysiology of gestational diabetes mellitus

JF Plows, JL Stanley, PN Baker, CM Reynolds… - International journal of …, 2018 - mdpi.com
Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women
without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In …

The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective

G Williamson, CD Kay, A Crozier - Comprehensive Reviews in …, 2018 - Wiley Online Library
Flavonoids are plant‐derived dietary components with a substantial impact on human
health. Research has expanded massively since it began in the 1930s, and the complex …

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

J Li, CYJ Sung, N Lee, Y Ni… - Proceedings of the …, 2016 - National Acad Sciences
The beneficial roles of probiotics in lowering the gastrointestinal inflammation and
preventing colorectal cancer have been frequently demonstrated, but their …

The role of osteoblasts in energy homeostasis

N Dirckx, MC Moorer, TL Clemens… - Nature Reviews …, 2019 - nature.com
Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …

Energy metabolism of the osteoblast: implications for osteoporosis

WC Lee, AR Guntur, F Long, CJ Rosen - Endocrine reviews, 2017 - academic.oup.com
Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …

[HTML][HTML] Observations on the ex situ perfusion of livers for transplantation

CJE Watson, V Kosmoliaptsis, C Pley, L Randle… - American journal of …, 2018 - Elsevier
Normothermic ex situ liver perfusion might allow viability assessment of livers before
transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 …

The SLC2 (GLUT) family of membrane transporters

M Mueckler, B Thorens - Molecular aspects of medicine, 2013 - Elsevier
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator
superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human …

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

EM Quistgaard, C Löw, F Guettou… - Nature Reviews Molecular …, 2016 - nature.com
Members of the major facilitator superfamily (MFS) of transport proteins are essential for the
movement of a wide range of substrates across biomembranes. As this transport requires a …