Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies
The SARS-CoV-2 pandemic at the end of 2019 had major worldwide health and economic
consequences. Until effective vaccination approaches were created, the healthcare sectors …
consequences. Until effective vaccination approaches were created, the healthcare sectors …
Exploring the anti-osteoporosis potential of Petroselinum crispum (Mill.) Fuss extract employing experimentally ovariectomized rat model and network pharmacology …
One of the most prevalent secondary osteoporosis is ovariectomy-induced osteoporosis.
Parsley (Petroselinum crispum) has potent estrogenic and antioxidant properties and was …
Parsley (Petroselinum crispum) has potent estrogenic and antioxidant properties and was …
[HTML][HTML] Combining In Vitro, In Vivo, and Network Pharmacology Assays to Identify Targets and Molecular Mechanisms of Spirulina-Derived Biomolecules against …
The current research employed an animal model of 7, 12-dimethylbenz (a) anthracene
(DMBA)-induced mammary gland carcinogenesis. The estrogen receptor-positive human …
(DMBA)-induced mammary gland carcinogenesis. The estrogen receptor-positive human …
Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1
KJ Rijpkema, M Schuller, MS van der Veer… - Organic …, 2024 - ACS Publications
Protein adenosine diphosphate (ADP)-ribosylation is crucial for a proper immune response.
Accordingly, viruses have evolved ADP-ribosyl hydrolases to remove these modifications, a …
Accordingly, viruses have evolved ADP-ribosyl hydrolases to remove these modifications, a …
Biochemical and molecular docking-based assessment of Spirulina platensis's bioactive constituents for their potential application as natural anticancer drug
Spirulina platensis and its extracts possess positive benefits for human health indications
from malnutrition, antioxidant properties, and therapeutic properties. This study investigates …
from malnutrition, antioxidant properties, and therapeutic properties. This study investigates …
Synthesis, antimicrobial, and in silico studies of c5′-O-substituted cytidine derivatives: cinnamoylation leads to improvement of antimicrobial activity
TS Bhuiyan, MA Said, MZH Bulbul… - … Nucleotides & Nucleic …, 2024 - Taylor & Francis
Nucleoside derivatives are important therapeutic drugs that have drawn significant attention
recently. In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N, N …
recently. In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N, N …