Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

J Zhang, R Cruz-Cosme, C Zhang, D Liu, Q Tang… - Mbio, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital
role in viral pathogenesis and coronavirus disease 2019 (COVID-19). Like the spike protein …

A novel diG motif in ORF3a protein of SARS-Cov-2 for intracellular transport

R Cruz-Cosme, J Zhang, D Liu, V Mahase… - Frontiers in Cell and …, 2022 - frontiersin.org
The ongoing SARS-CoV-2/COVID-19 pandemic caused a global public health crisis. Yet,
everyone's response to SARS-CoV-2 infection varies, and different viral variants confer …

Basal interaction of the orphan receptor GPR101 with arrestins leads to constitutive internalization

D Abboud, C Abboud, A Inoue, JC Twizere… - Biochemical …, 2024 - Elsevier
GPR101 is an orphan G protein-coupled receptor that promotes growth hormone secretion
in the pituitary. The microduplication of the GPR101 gene has been linked with the X-linked …

DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish

BP Madakashira, E Magnani, S Ranjan… - Nucleic Acids …, 2024 - academic.oup.com
Coordinating epigenomic inheritance and cell cycle progression is essential for
organogenesis. UHRF1 connects these functions during development by facilitating …

Antibody uptake assay for tracking Notch/Delta endocytosis during the asymmetric division of zebrafish radial glia progenitors

X Zhao, S Guo - JoVE (Journal of Visualized Experiments), 2023 - jove.com
Asymmetric cell division (ACD), which produces two daughter cells of different fates, is
fundamental for generating cellular diversity. In the developing organs of both invertebrates …

PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate

X Zhao, W Yiqi, AC Solak, J Garcia, V Mouilleau… - bioRxiv, 2024 - biorxiv.org
Vertebrate radial glia progenitors (RGPs), the principal neural stem cells, balance self-
renewal and differentiation through asymmetric cell division (ACD), during which unequal …