RNA G-quadruplexes in biology: principles and molecular mechanisms

MM Fay, SM Lyons, P Ivanov - Journal of molecular biology, 2017 - Elsevier
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …

[HTML][HTML] G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome

R Simone, P Fratta, S Neidle, GN Parkinson, AM Isaacs - FEBS letters, 2015 - Elsevier
G-rich sequences in DNA and RNA have a propensity to fold into stable secondary
structures termed G-quadruplexes. G-quadruplex forming sequences are widespread …

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

Detection of genomic G-quadruplexes in living cells using a small artificial protein

K Zheng, J Zhang, Y He, J Gong, C Wen… - Nucleic acids …, 2020 - academic.oup.com
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …

G-Quadruplex: a regulator of gene expression and its chemical targeting

T Tian, YQ Chen, SR Wang, X Zhou - Chem, 2018 - cell.com
Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …

Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution

F Wu, K Niu, Y Cui, C Li, M Lyu, Y Ren, Y Chen… - Communications …, 2021 - nature.com
Abstract G-quadruplex (G4) structures have been predicted in the genomes of many
organisms and proven to play regulatory roles in diverse cellular activities. However, there is …

RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation

E Dardenne, MP Espinoza, L Fattet, S Germann… - Cell reports, 2014 - cell.com
The RNA helicases DDX5 and DDX17 are members of a large family of highly conserved
proteins that are involved in gene-expression regulation; however, their in vivo targets and …

Structure and function of multimeric G-quadruplexes

S Kolesnikova, EA Curtis - Molecules, 2019 - mdpi.com
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …

Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery

NG Dolinnaya, AM Ogloblina, MG Yakubovskaya - Biochemistry (Moscow), 2016 - Springer
Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …

Alternative splicing modulation by G-quadruplexes

I Georgakopoulos-Soares, GE Parada… - Nature …, 2022 - nature.com
Alternative splicing is central to metazoan gene regulation, but the regulatory mechanisms
are incompletely understood. Here, we show that G-quadruplex (G4) motifs are enriched~ 3 …