There is a strong graft-versus-leukemia (GVL) effect of allogeneic stem cell transplantation
(SCT) due to elimination of tumor cells by alloimmune effector lymphocytes. When leukemia …

Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that
binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting …

Adenovirus (AdV) infections are very common in the general pediatric population. The
delayed clearance in young persons imposes a threat to immunocompromised patients after …

The major challenge in allogeneic hematopoietic cell transplantation is how to transfer
allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we …

Hematopoietic stem cell transplantation has evolved as a central treatment modality in the
management of different hematologic malignancies. Despite adequate posttransplantation …

Poor T lymphocyte reconstitution limits the use of haploidentical stem cell transplantation
(SCT) because it results in a high mortality from viral infections. One approach to overcome …

Background Allogeneic haemopoietic stem-cell transplantation (HSCT) is the treatment of
choice for many haemological malignancies and inherited disorders. When stem cells for …

Immunotoxins are composed of a protein toxin connected to a binding ligand such as an
antibody or growth factor. These molecules bind to surface antigens (which internalize) and …

Hematopoietic stem cell transplantation (HSCT) is the definitive cure for many malignant and
nonmalignant diseases. However, delays in immune reconstitution (IR) following HSCT …

BACKGROUND AND OBJECTIVE: Cell therapy can be considered as a strategy aimed at
replacing, repairing, or enhancing the biological function of a damaged tissue or system by …