Aggregatibacter actinomycetemcomitans is an oral pathogen that produces the RTX toxin,
leukotoxin (LtxA; Leukothera®). A. actinomycetemcomitans is strongly associated with the …

Illustrated here is the critical role of oncogenic KRAS in the initiation of cancer through
deregulation of the G1 cell cycle, and elements and scenarios taking place under …

Immune responses need to be tightly controlled to avoid excessive inflammation and
prevent unwanted host damage. Here we report that germinal center kinase MST4 …

Rassf1A/5 tumor suppressors serve as adaptor proteins possessing a modular architecture
with the C-terminal consisting of a coiled-coil SARAH (Salvador-Rassf-Hippo) domain and …

As a tumor suppressor, RASSF5 (NORE1A) activates MST1/2 thereby modulating the Hippo
pathway. Structurally, activation involves RASSF5 and MST1/2 swapping their SARAH …

The mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC)
protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation …

The Hippo pathway serves as a key barrier for oncogenic transformation. It acts by limiting
the activity of the proto-oncogenes YAP and TAZ. Reduced Hippo signaling and elevated …

Repeats‐in‐toxin leukotoxin (LtxA) produced by the oral bacterium Aggregatibacter
actinomycetemcomitans kills human leukocytes in a lymphocyte function‐associated antigen …

RASSF enzymes act as key apoptosis activators and tumor suppressors, being
downregulated in many human cancers, although their exact regulatory roles remain …

During development, the Hippo pathway regulates the balance between cell proliferation
and apoptosis to control organ size. Appropriate Hippo signaling is associated with stem cell …