MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Failure of embryo implantation is a major limiting factor in early pregnancy and assisted
reproduction. Determinants of implantation include the embryo viability, the endometrial …

The nucleolytic activity of animal Argonaute proteins is deeply conserved, despite its having
no obvious role in microRNA-directed gene regulation. In mice, Ago2 (also known as Eif2c2) …

The highly conserved Argonaute protein family members play a central role in the regulation
of gene expression networks, orchestrating the establishment and the maintenance of cell …

MicroRNAs (miRNAs) contribute to the progressive changes in gene expression that occur
during development. The combined loss of all miRNAs results in embryonic lethality in all …

MicroRNAs (miRNAs) are small, noncoding RNAs that mediate posttranscriptional gene
suppression in a sequence-specific manner. The ability of a single miRNA species to target …

The genetic codes inscribed during two key developmental processes, namely
gametogenesis and embryogenesis, are believed to determine subsequent development …

In placental mammals, reproductive success, and maternal-fetal health substantially depend
on a well-being placenta, the interface between the fetus and the mother. Disorders in …

Argonaute (Ago) 2 is the catalytic engine of mammalian RNA interference, but little is known
concerning the regulation of Ago2 by cell-signaling pathways. In this study we show that …

Activation of zygotic gene expression in the two-cell mouse embryo is associated with
destruction of maternally inherited transcripts, an important process for embryogenesis …