Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Measuring precise concentrations of proteins can provide insights into biological processes.
Here we use efficient protein extraction and sample fractionation, as well as state-of-the-art …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Protein function is regulated by diverse posttranslational modifications. The mitochondrial
sirtuin SIRT5 removes malonyl and succinyl moieties from target lysines. The spectrum of …

Protein acetylation is a well-studied regulatory mechanism for several cellular processes,
ranging from gene expression to metabolism. Recent discoveries of new post-translational …

Protein lysine acetylation has emerged as a key posttranslational modification in cellular
regulation, in particular through the modification of histones and nuclear transcription …

Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

Of the 20 ribosomally coded amino acid residues, lysine is the most frequently post-
translationally modified, which has important functional and regulatory consequences. Here …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …