Alpha-1-antitrypsin (AAT), an acute-phase protein encoded by the SERPINA1 gene, is a
member of the serine protease inhibitor (SERPIN) superfamily. Its primary function is to …

Clinical heterogeneity has been demonstrated in alpha-1 antitrypsin deficiency (AATD),
such that clinical suspicion plays an important role in its diagnosis. The PiZZ genotype is the …

Abstract Alpha1-antitrypsin (AAT) is a serum protease inhibitor that rises during inflammation
and healthy pregnancies. Plasma-derived AAT, indicated for genetic AAT deficiency, is …

Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients
suffering from respiratory or cardiac failure. The ECMO-associated morbidity and mortality …

Protecting tissues from excessive inflammation by glucocorticoids results in an effective
blockade of inflammation; however, it does not instigate processes of inflammatory …

Since the COVID-19 pandemic alarm was made by the severe acute respiratory syndrome
(SARS)-coronavirus (CoV) 2, several institutions and agencies have pursued to clarify the …

The acute phase protein α1-antitrypsin (AAT) inhibits numerous proteases, specifically
neutrophil elastase. Patients with an AAT deficiency due to mutations frequently develop …

Immunosuppressive drugs are an inherent component of hematopoietic stem cell
transplantation (HSCT) for the prevention of acute graft-versus-host disease (GVHD) …

Background. Wound healing requires a delicate balance between cellular and molecular
factors, all affected by reactive oxygen species (ROS). While ROS decontaminate, they also …

Transient vestibular organ deafferentation, such that is caused by traumatic tissue injury, is
presently addressed by corticosteroid therapy. However, restoration of neurophysiological …