As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

Sepsis, defined as the dysregulated immune response to an infection leading to organ
dysfunction, is one of the leading causes of mortality around the globe. Despite the …

Abstract Background and Purpose: Corneal injury can result in dysfunction of corneal
nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system …

The cannabinoid CB2 receptor was cloned from the promyeloid cell line HL-60 and is
notably expressed in most, if not all leukocyte types. This relatively restricted localization …

Background Sepsis-induced cardiomyopathy (SIC) is a common severe complication of
sepsis that contributes to mortality. SIC is closely associated with excessive inflammatory …

The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis
has been used for several millennia to treat inflammatory disorders such as rheumatism or …

Toll-like receptors (TLRs) have become a focus in biomedicine and biomedical research
given the roles of this unique family of innate immune proteins in immune activation …

Cannabinoid receptor (CB) 2 is an immune cell–localized GPCR that has been
hypothesized to regulate the magnitude of inflammatory responses. However, there is …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from loss of insulin-
secreting β-cells in islets of Langerhans. The loss of β-cells is initiated when self-tolerance to …

Background The endocannabinoid system (ECS) is composed of cannabinoid receptors
type 1 (CBR1) and type 2 (CBR2), cannabinoid‐based ligands (endogenous chemically …