[HTML][HTML] Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …
[PDF][PDF] Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
In mammals, white adipose tissues are largely divided into visceral epididymal adipose
tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic …
tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic …
Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis
Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …
[HTML][HTML] Flt1 produced by lung endothelial cells impairs ATII cell transdifferentiation and repair in pulmonary fibrosis
MC Volpe, G Ciucci, G Zandomenego, R Vuerich… - Cell Death & …, 2023 - nature.com
Pulmonary fibrosis is a devastating disease, in which fibrotic tissue progressively replaces
lung alveolar structure, resulting in chronic respiratory failure. Alveolar type II cells act as …
lung alveolar structure, resulting in chronic respiratory failure. Alveolar type II cells act as …
[HTML][HTML] Extracellular vesicles in organ fibrosis: mechanisms, therapies, and diagnostics
DR Brigstock - Cells, 2021 - mdpi.com
Fibrosis is the unrelenting deposition of excessively large amounts of insoluble interstitial
collagen due to profound matrigenic activities of wound-associated myofibroblasts during …
collagen due to profound matrigenic activities of wound-associated myofibroblasts during …
Multiple fibroblast subtypes contribute to matrix deposition in pulmonary fibrosis
Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
Conformations, interactions and functions of intrinsically disordered syndecans
S Ricard-Blum, JR Couchman - Biochemical Society …, 2023 - portlandpress.com
Syndecans are transmembrane heparan sulfate proteoglycans present on most mammalian
cell surfaces. They have a long evolutionary history, a single syndecan gene being …
cell surfaces. They have a long evolutionary history, a single syndecan gene being …
[PDF][PDF] Categorization of lung mesenchymal cells in development and fibrosis
Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …
development and disease states. They are increasingly recognized as highly …
[HTML][HTML] Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate …
Background Although it is becoming evident that individual's immune system has a decisive
influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this …
influence on SARS-CoV-2 disease progression, pathogenesis is largely unknown. In this …