The role of peroxisome proliferator-activated receptors (PPAR) in immune responses
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
Breakthroughs in therapies for NASH and remaining challenges
V Ratziu, S Francque, A Sanyal - Journal of hepatology, 2022 - Elsevier
Initially a condition that received limited recognition and whose clinical impact was
controversial, non-alcoholic steatohepatitis (NASH) has become a leading cause of chronic …
controversial, non-alcoholic steatohepatitis (NASH) has become a leading cause of chronic …
Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity
A Carazo, K Macáková, K Matoušová, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …
Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors
S Francque, G Szabo, MF Abdelmalek… - Nature reviews …, 2021 - nature.com
The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …
Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS
L Liang, Y Pan, L Bin, Y Liu, W Huang, R Li, KP Lai - Chemosphere, 2022 - Elsevier
Perfluorinated and polyfluorinated compounds (PFASs) are a class of synthetic chemical
substances that are widely used in human production and life, such as fire-fighting foams …
substances that are widely used in human production and life, such as fire-fighting foams …
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …
disease, has emerged as a major public health problem, more efficient therapeutics of which …
Mitonuclear communication in homeostasis and stress
Mitochondria participate in crucial cellular processes such as energy harvesting and
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …
De Novo Design of Bioactive Small Molecules by Artificial Intelligence
Generative artificial intelligence offers a fresh view on molecular design. We present the first‐
time prospective application of a deep learning model for designing new druglike …
time prospective application of a deep learning model for designing new druglike …
Current anti-diabetic agents and their molecular targets: A review
Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …
blood sugar. The frequency of diagnosed cases and consequential increases in medical …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …