Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …

The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues
and returns it to the blood. Lymphatic vessels are also an essential part of the body's …

Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue
homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding …

Lymphangiogenesis, an important initial step in tumor metastasis and transplant
sensitization, is mediated by the action of VEGF-C and-D on VEGFR3. In contrast, VEGF-A …

The vascular system is locally specialized to accommodate widely varying blood flow and
pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the …

Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …

This work describes the formation, perfusion, and maturation of three-dimensional
microvascular tubes in vitro. These tubes consisted of confluent monolayers of human …

Removal of cholesterol from peripheral tissues to the bloodstream via reverse cholesterol
transport (RCT) is a process of major biological importance. Here we demonstrate that …