The intertwined physics of active chemical reactions and phase separation

D Zwicker - Current Opinion in Colloid & Interface Science, 2022 - Elsevier
Phase separation is the thermodynamic process that explains how droplets form in
multicomponent fluids. These droplets can provide controlled compartments to localize …

Circuit theory for chemical reaction networks

F Avanzini, N Freitas, M Esposito - Physical Review X, 2023 - APS
We lay the foundation of a circuit theory for chemical reaction networks. Chemical reactions
are grouped into chemical modules solely characterized by their current-concentration …

Thermodynamic uncertainty relation and thermodynamic speed limit in deterministic chemical reaction networks

K Yoshimura, S Ito - Physical review letters, 2021 - APS
We generalize the thermodynamic uncertainty relation (TUR) and thermodynamic speed
limit (TSL) for deterministic chemical reaction networks (CRNs). The scaled diffusion …

Information thermodynamics for deterministic chemical reaction networks

E Penocchio, F Avanzini, M Esposito - The Journal of Chemical …, 2022 - pubs.aip.org
Information thermodynamics relates the rate of change of mutual information between two
interacting subsystems to their thermodynamics when the joined system is described by a …

Nonequilibrium thermodynamics of non-ideal chemical reaction networks

F Avanzini, E Penocchio, G Falasco… - The Journal of Chemical …, 2021 - pubs.aip.org
All current formulations of nonequilibrium thermodynamics of open chemical reaction
networks rely on the assumption of non-interacting species. We develop a general theory …

Nonequilibrium thermodynamics of light-induced reactions

E Penocchio, R Rao, M Esposito - The Journal of Chemical Physics, 2021 - pubs.aip.org
Current formulations of nonequilibrium thermodynamics of open chemical reaction networks
only consider chemostats as free-energy sources sustaining nonequilibrium behaviors …

Free-energy transduction in chemical reaction networks: From enzymes to metabolism

A Wachtel, R Rao, M Esposito - The Journal of Chemical Physics, 2022 - pubs.aip.org
We provide a rigorous definition of free-energy transduction and its efficiency in arbitrary—
linear or nonlinear—open chemical reaction networks (CRNs) operating at a steady state …

Local detailed balance across scales: From diffusions to jump processes and beyond

G Falasco, M Esposito - Physical Review E, 2021 - APS
Diffusive dynamics in presence of deep energy minima and weak nongradient forces can be
coarse grained into a mesoscopic jump process over the various basins of attraction …

Calcium oscillations optimize the energetic efficiency of mitochondrial metabolism

V Voorsluijs, F Avanzini, G Falasco, M Esposito… - Iscience, 2024 - cell.com
Energy transduction is central to living organisms, but the impact of enzyme regulation and
signaling on its thermodynamic efficiency is generally overlooked. Here, we analyze the …

Thermodynamics for reduced models of chemical reactions by PEA and QSSA

L Peng, L Hong - Physical Review Research, 2024 - APS
The partial equilibrium approximation (PEA) and the quasi-steady-state approximation
(QSSA) are two classical methods for reducing complex macroscopic chemical reactions …