Free radicals generated within subcellular compartments damage macromolecules which
lead to severe structural changes and functional alterations of cellular organelles. A …

Alzheimer's disease (AD) is a highly complex neurodegenerative disorder of the aged that
has multiple factors which contribute to its etiology in terms of initiation and progression. This …

The cytoskeleton is a phylogenetically well‐preserved structure that plays a key role in cell
physiology. Dynamic and differential changes in cytoskeletal organization occur in cellular …

Background: Melatonin is synthesized and secreted by the pineal gland and other organs.
The pattern of melatonin secretion is controlled by an endogenous circadian timing system …

The cell membrane plays an important role in the molecular mechanism of amyloid toxicity
associated with Alzheimer's disease. The membrane's chemical composition and the …

Levels of melatonin in mammalian circulation are well documented; however, its levels in
tissues and other body fluids are yet only poorly established. It is obvious that melatonin …

Human life expectancy has increased over the past 50 years due to scientific and medical
advances and higher food availability. However, overweight and obesity affect more than …

Background: The antioxidant and anti‐inflammatory hormone melatonin is secreted by
saliva into the oral cavity, where it may protect the mucosal and gingival tissues from radical …

Heart mitochondria from female senescence-accelerated (SAMP8) and senescence-
resistant (SAMR1) mice of 5 or 10 months of age, were studied. Mitochondrial oxidative …

The role of the oral cavity in the pathogenesis of diseases of various systems such as the
gastro-intestinal tract (GIT), cardiovascular and immune systems has been recently …