Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …

The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …

Over the last decades, cancer immunotherapies such as checkpoint blockade and adoptive
T cell transfer have been a game changer in many aspects and have improved the treatment …

ABSTRACT Immunoglobulin G1 (IgG1) is the most abundant circulating human antibody
and also the scaffold for many therapeutic monoclonal antibodies (mAbs). The destruction of …

The function of the low-affinity IgG-receptor FcγRIIIb (CD16b), which is uniquely and
abundantly expressed on human granulocytes, is not clear. Unlike the other Fcγ receptors …

Today, monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in
cancer therapy especially for the patients with advanced or metastatic cancers. Efficacy of …

The targeting of surface antigens expressed on tumor cells by monoclonal antibodies
(mAbs) has revolutionized cancer therapeutics. One mechanism of action of antibody-based …

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

The human fragment crystallizable (Fc) γ receptor (R) interacts with antigen‐complexed
immunoglobulin (Ig) G ligands to both activate and modulate a powerful network of …

Herein, we describe the generation of potent NK cell engagers (NKCEs) based on single
domain antibodies (sdAbs) specific for NKp46 harboring the humanized Fab version of …