The two major cellular sites for membrane protein degradation are the proteasome and the
lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal …

The pathways that deliver newly synthesized proteins that reside in lysosomes are well
understood on comparison with our knowledge of how integral membrane proteins are …

Selective ubiquitin-dependent autophagy plays a pivotal role in the elimination of protein
aggregates, assemblies, or organelles and counteracts the cytotoxicity of proteins linked to …

Protein localisation and translocation between intracellular compartments underlie almost
all physiological processes. The hyperLOPIT proteomics platform combines mass …

Multiple mitochondrial quality control pathways exist to maintain the health of mitochondria
and ensure cell homeostasis. Here, we investigate the role of the endosomal adaptor Tollip …

Cystic fibrosis (CF) is one of the most common lethal genetic diseases in which the role of
microRNAs has yet to be explored. Predicted to be regulated by miR-126, TOM1 (target of …

Low-dose endotoxemia is prevalent in humans with adverse health conditions, and it
correlates with the pathogenesis of chronic inflammatory diseases such as atherosclerosis …

Abstract Background and Objectives Clathrin is an adaptor protein that serves as the
principal element of the vesicle-coating complex and is important for the membrane …

To identify novel tyrosine kinase substrates that have never been implicated in cancer, we
studied the phosphoproteomic changes in the MCF10AT model of breast cancer …

Summary Interleukin-1 receptor (IL-1RI) is a master regulator of inflammation and innate
immunity [1]. When triggered by IL-1β, IL-1RI aggregates with IL-1R-associated protein (IL …