In this review we examine the mechanisms (causes) underlying the increased glucose
consumption observed in tumors within a teleological context (consequences). In other …

Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-
associated proteins encoded by immediate early genes that play various roles in …

Melanomas are very aggressive neoplasms with notorious resistance to therapeutics. It was
recently proposed that the remarkable phenotypic plasticity of melanoma cells allows for the …

Neonates with intrauterine growth restriction (IUGR) are prone to suffer from digestive
diseases. Using neonatal pigs with IUGR, we tested the hypothesis that IUGR may induce …

Microphthalmia-associated transcription factor (MITF) regulates normal melanocyte
development and is also a lineage-selective oncogene implicated in melanoma and clear …

Cancer is a leading cause of death and still awaits effective therapies. Rapid
industrialization has contributed to increase in incidence of cancer. One of the reasons why …

Purpose: Corneal neovascularization and scarring commonly lead to significant vision loss.
This study was designed to determine whether a small-molecule inhibitor of galectin-3 can …

Oligodendrocyte progenitor cells (OPCs) are responsible for remyelination in the central
nervous system (CNS) in health and disease. For patients with multiple sclerosis (MS) …

Galectin-3 (gal-3) is a β-galactoside binding protein related to many tumoral aspects, eg.
angiogenesis, cell growth and motility and resistance to cell death. Evidence has shown its …

Glioma is the most commonly observed primary intracranial tumour and is associated with
massive angiogenesis. Glioma neovascularization provides nutrients for the growth and …