Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Osteosarcoma (OS) is a relatively rare tumor of bone with a worldwide incidence of 3.4
cases per million people per year. For most of the twentieth century, five-year survival rates …

Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

Wound instability and poor functional vascularization in bone tissue engineering lead to lack
of tissue integration and ultimate failure of engineered grafts. In order to harness the …

Osteosarcoma (OS), the most common primary bone tumor, is highly metastatic with high
chemotherapeutic resistance and poor survival rates. Using induced pluripotent stem cells …

The outcome for metastatic pediatric osteosarcoma (OS) remains poor. Thus, there is an
urgent need to develop novel therapies, and immunotherapy with CAR T cells has the …

Predictive testing of anticancer drugs remains a challenge. Bioengineered systems,
designed to mimic key aspects of the human tumor microenvironment, are now improving …

Background Currently, the clinical prediction model for patients with osteosarcoma was
almost developed from single-center data, lacking external validation. Due to their low …

Ewing sarcoma is the second-most-common bone cancer in children. Driven by an
oncogenic chromosomal translocation that results in the expression of an aberrant …

Background Osteosarcoma (OS) is the most common pediatric primary malignant bone
tumor. As the prognosis for patients following standard treatment did not improve for almost …