Reconciling the distinct roles of angiogenic/anti-angiogenic factors in the placenta and maternal circulation of normal and pathological pregnancies

A Umapathy, LW Chamley, JL James - Angiogenesis, 2020 - Springer
A branched vascular network is crucial to placental development and is dependent on
factors such as vascular endothelial growth factor (VEGF), placental growth factor (PlGF) …

[HTML][HTML] Role of nitric oxide in placental vascular development and function

BJ Krause, MA Hanson, P Casanello - Placenta, 2011 - Elsevier
Nitric oxide (NO) is one of the most pleiotropic signaling molecules at systemic and cellular
levels, participating in vascular tone regulation, cellular respiration, proliferation, apoptosis …

Intrauterine growth restriction—etiology and consequences: what do we know about the human situation and experimental animal models?

Z Ergaz, M Avgil, A Ornoy - Reproductive Toxicology, 2005 - Elsevier
Embryonic and fetal growth depend on genetic and environmental factors, and the process
is the result of the interaction between these factors. About 7–9% of live-born infants have a …

Angiogenesis in implantation

DS Torry, J Leavenworth, M Chang… - Journal of assisted …, 2007 - Springer
Problem Implantation failure and early pregnancy loss are common following natural
conceptions and they are particularly important clinical hurdles to overcome following …

Endothelial eNOS/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels

BJ Krause, I Carrasco-Wong, A Caniuguir, J Carvajal… - Placenta, 2013 - Elsevier
Placental vascular tone is critically influenced by nitric oxide (NO) derived from endothelial
NO synthase (eNOS) activity. Placental vessels from pregnancies complicated with …

Endothelial dysfunction in pregnancy complications

J Kornacki, P Gutaj, A Kalantarova, R Sibiak… - Biomedicines, 2021 - mdpi.com
The endothelium, which constitutes the inner layer of blood vessels and lymphatic
structures, plays an important role in various physiological functions. Alterations in structure …

Placental growth factor is a potent vasodilator of rat and human resistance arteries

G Osol, G Celia, N Gokina, C Barron… - American Journal …, 2008 - journals.physiology.org
The objectives of this study were to determine whether placental growth factor (PlGF) exerts
a vasodilatory effect on rat uterine vessels (arcuate arteries and veins) and to examine …

Placental treatment with insulin-like growth factor 1 via nanoparticle differentially impacts vascular remodeling factors in guinea pig sub-placenta/decidua

BN Davenport, HN Jones, RL Wilson - Frontiers in physiology, 2023 - frontiersin.org
Clinically, fetal growth restriction (FGR) is only detectable in later gestation, despite
pathophysiological establishment likely earlier in pregnancy. Additionally, there are no …

The gonadotropins: tissue-specific angiogenic factors?

K Reisinger, N Baal, T McKinnon, K Münstedt… - Molecular and cellular …, 2007 - Elsevier
The gonadotropins, whose members are human chorionic gonadotropin (hCG), lutenizing
hormone (LH) and follicle-stimulating hormone (FSH) are a well characterized hormone …

Signaling regulation of fetoplacental angiogenesis

K Wang, J Zheng - The Journal of endocrinology, 2011 - pmc.ncbi.nlm.nih.gov
During normal pregnancy, dramatically increased placental blood flow is critical for fetal
growth and survival as well as neonatal birth weights and survivability. This increased blood …