Titin has long been recognized as a mechanical protein in muscle cells that has a main
function as a molecular spring in the contractile units, the sarcomeres. Recent work suggests …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

The important protozoan parasites including Plasmodium, Leishmania, Toxoplasma,
Trypanosoma and Giardia have been proved as the main reason initiating and developing …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Muscle has conventionally been viewed as a motor that converts chemical to kinetic energy
in series with a passive spring, but new insights emerge when muscle is viewed as a …

Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere,
responsible for passive force development at sarcomere length (SL) above the physiological …

Targeted and nontargeted metabolomics has the potential to evaluate and detect global
metabolite changes in biological systems. Direct infusion mass spectrometric analysis …

Eccentric muscle loading encompasses several unique features compared to other types of
contractions. These features include increased force, work, and performance at decreased …

The force developed by actively lengthened muscle depends on different structures across
different scales of lengthening. For small perturbations, the active response of muscle is well …

Biointerfaced sensors have emerged as a new paradigm for medical applications that
require an interface and/or intimate contact with biological components/systems such as …