Unlocking the bacterial membrane as a therapeutic target for next-generation antimicrobial amphiphiles
Gram-positive bacteria like Enterococcus faecium and Staphylococcus aureus, and Gram-
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
Recent progress in bile acid-based antimicrobials
C Lin, Y Wang, M Le, KF Chen, YG Jia - Bioconjugate Chemistry, 2021 - ACS Publications
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …
Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms
Inspired by the facial amphiphilic nature and antimicrobial efficacy of many antimicrobial
peptides, this work reported facial amphiphilic bicyclic naphthoic acid derivatives with …
peptides, this work reported facial amphiphilic bicyclic naphthoic acid derivatives with …
[HTML][HTML] Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy
Facial amphiphilicity is an extraordinary chemical structure feature of a variety of
antimicrobial peptides and polymers. Vast efforts have been dedicated to small molecular …
antimicrobial peptides and polymers. Vast efforts have been dedicated to small molecular …
[HTML][HTML] Prophylactic vs. therapeutic effect of probiotics on the inflammation mediated by the NF-κb pathway in inflammatory bowel conditions
Probiotic supplements consumed adequately at the proper time can affect health by
modulating inflammatory pathways in gastrointestinal epithelial cells and modifying the …
modulating inflammatory pathways in gastrointestinal epithelial cells and modifying the …
Cholic acid-peptide conjugates as potent antimicrobials against interkingdom polymicrobial biofilms
Interkingdom polymicrobial biofilms formed by Gram-positive Staphylococcus aureus and
Candida albicans pose serious threats of chronic systemic infections due to the absence of …
Candida albicans pose serious threats of chronic systemic infections due to the absence of …
Recent advances in steroid amino acid conjugates: Old scaffolds with new dimensions
P Singla, DB Salunke - European Journal of Medicinal Chemistry, 2020 - Elsevier
Hybrid chemical compounds formed by conjugation of two or more bioactive molecules have
shown wide variety of applications in biology, microelectronics as well as material sciences …
shown wide variety of applications in biology, microelectronics as well as material sciences …
Deciphering the role of intramolecular networking in cholic acid–peptide conjugates on the lipopolysaccharide surface in combating gram-negative bacterial infections
The presence of lipopolysaccharide and emergence of drug resistance make the treatment
of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis …
of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis …
Recent advances in biomedical applications of cholic acid-based macromolecules
In recent decades, polymeric materials have been extensively investigated for their
widespread therapeutic applications in various biomedical fields. In particular, biomolecule …
widespread therapeutic applications in various biomedical fields. In particular, biomolecule …
The great ESKAPE: exploring the crossroads of bile and antibiotic resistance in bacterial pathogens
KS Gipson, KP Nickerson, E Drenkard… - Infection and …, 2020 - Am Soc Microbiol
Throughout the course of infection, many pathogens encounter bactericidal conditions that
threaten the viability of the bacteria and impede the establishment of infection. Bile is one of …
threaten the viability of the bacteria and impede the establishment of infection. Bile is one of …