The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-
proteasome system that recruits substrates such as the hypoxia inducible factor for …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …

Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancer cases and
is characterized by the absence of estrogen, progesterone, and human epidermal growth …

Purpose The cyclin D-cyclin dependent kinase (CDK) 4/6-inhibitor of CDK4 (INK4)-
retinoblastoma (Rb) pathway plays a crucial role in cell cycle progression and its …

Data on real-world effectiveness of cyclin-dependent kinase 4/6 inhibitor combination
therapy versus endocrine therapy alone are limited. The Flatiron Health Analytic Database …

Cyclin-dependent kinase 6 (CDK6) is an important regulator of the cell cycle. Together with
CDK4, it phosphorylates and inactivates retinoblastoma (Rb) protein. In tumour cells, CDK6 …

Cell cycle dysregulation is a hallmark of cancer that promotes eccessive cell division. Cyclin-
dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6) are key molecules in …

Dysregulated activation of the cyclin-dependent kinases (CDKs) 4/6, leading to uncontrolled
cell division, is hallmark of cancers. Further study of the cell cycle will advance the cancer …

Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a
poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of …