Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Apoptosis is a prominent feature of liver diseases. Causative factors such as alcohol,
viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell …

The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …

The partial cross-utilization of molecules and pathways involved in opposing processes like
cell survival, proliferation and cell death, assures that mutations within one signaling …

Ischaemia-induced tissue injury has wide-ranging clinical implications including myocardial
infarction, stroke, compartment syndrome, ischaemic renal failure and replantation and …

The complex formed by two members of the S100 calcium-binding protein family,
S100A8/A9, exerts apoptosis-inducing activity in various cells of different origins. Here, we …

Brevinin‐2R is a novel non‐hemolytic defensin that was isolated from the skin of the frog
Rana ridibunda. It exhibits preferential cytotoxicity towards malignant cells, including Jurkat …

Clinical studies have shown that HER-2/Neu is over-expressed in up to one-third of patients
with a variety of cancers, including B-cell acute lymphoblastic leukemia (B-ALL), breast …

In hepatic toxicity induced in rats by two injections of thioacetamide (TAA, 350 mg/kg with an
interval of 8 hr), the action of quercetin was investigated. After 96 hr, TAA administration …