Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a
cell population harbored in a highly regulated niche located at the limbus. Dysfunction …

Purpose: Despite extensive knowledge gained over the last 3 decades regarding limbal
stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of …

Purpose: In recent decades, the medical and surgical treatment of limbal stem cell deficiency
(LSCD) has evolved significantly through the incorporation of innovative pharmacological …

Purpose Dry eye disease (DED) is a common and multifactor-induced autoimmune ocular
surface disease. Environmental factors, such as desiccating stress (DS) and …

Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of
cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and …

Background Ocular surface burns can be caused by chemicals (alkalis and acids) or by
direct heat. Amniotic membrane transplantation (AMT) performed in the acute phase (day 0 …

Destruction of the limbus and depletion of limbal stem cells (LSCs), the adult progenitors of
the corneal epithelium, leads to limbal stem cell deficiency (LSCD). LSCD is a rare …

Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or
bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first …

Human amniotic membrane (AM) offers unique advantages as a matrix to support the
transplantation of limbal stem cells (LSCs) due to its inherent pro-regenerative and anti …