Circuits and functions of the lateral habenula in health and in disease
H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …
owing to new discoveries relating to its critical role in regulating negatively motivated …
[HTML][HTML] Lateral habenula in the pathophysiology of depression
Depression is a devastating disorder with a combination of diverse symptoms such as low
self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort …
self-esteem, lack of motivation, anhedonia, loss of appetite, low energy, and discomfort …
Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5–B9) to the forebrain and brainstem
A Muzerelle, S Scotto-Lomassese, JF Bernard… - Brain Structure and …, 2016 - Springer
Serotoninergic innervation of the central nervous system is provided by hindbrain raphe
nuclei (B1–B9). The extent to which each raphe subdivision has distinct topographic …
nuclei (B1–B9). The extent to which each raphe subdivision has distinct topographic …
An excitatory synapse hypothesis of depression
Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …
deficits in emotional and cognitive processing remain incompletely understood. Current …
Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns
J Ko - Frontiers in neural circuits, 2017 - frontiersin.org
Social behavior encompasses a number of distinctive and complex constructs that form the
core elements of human imitative culture, mainly represented as either affiliative or …
core elements of human imitative culture, mainly represented as either affiliative or …
An update on the role of serotonin and its interplay with dopamine for reward
AG Fischer, M Ullsperger - Frontiers in human neuroscience, 2017 - frontiersin.org
The specific role of serotonin and its interplay with dopamine (DA) in adaptive, reward
guided behavior as well as drug dependance, still remains elusive. Recently, novel methods …
guided behavior as well as drug dependance, still remains elusive. Recently, novel methods …
The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger
Anticipation of danger at first elicits panic in animals, but later it helps them to avoid the real
threat adaptively. In zebrafish, as fish experience more and more danger, neurons in the …
threat adaptively. In zebrafish, as fish experience more and more danger, neurons in the …
Dysregulation of the lateral habenula in major depressive disorder
CA Browne, R Hammack, I Lucki - Frontiers in synaptic neuroscience, 2018 - frontiersin.org
Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in
the development of psychiatric disorders including major depressive disorder (MDD). This …
the development of psychiatric disorders including major depressive disorder (MDD). This …
Serotonin release in the habenula during emotional contagion promotes resilience
Negative emotional contagion—witnessing others in distress—affects an individual's
emotional responsivity. However, whether it shapes coping strategies when facing future …
emotional responsivity. However, whether it shapes coping strategies when facing future …
Efferent pathways of the mouse lateral habenula
The lateral habenula (LHb) is part of the habenula complex of the dorsal thalamus. Recent
studies of the LHb have focused on its projections to the ventral tegmental area (VTA) and …
studies of the LHb have focused on its projections to the ventral tegmental area (VTA) and …