Therapeutic oxygen delivery by perfluorocarbon-based colloids

MP Krafft, JG Riess - Advances in colloid and interface science, 2021 - Elsevier
After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

A role for nanoparticles in treating traumatic brain injury

B Alam Bony, FM Kievit - Pharmaceutics, 2019 - mdpi.com
Traumatic brain injury (TBI) is one of the main causes of disability in children and young
adults, as well as a significant concern for elderly individuals. Depending on the severity, TBI …

The clustered DNA lesions–types, pathways of repair and relevance to human health

B Bukowska, BT Karwowski - Current Medicinal Chemistry, 2018 - ingentaconnect.com
The clustered DNA lesions are a characteristic feature of ionizing radiation and are defined
as two or more damage sites formed within 20 bps after the passage of a single radiation …

Functional, metabolic and morphologic results of ex vivo donor lung perfusion with a perfluorocarbon-based oxygen carrier nanoemulsion in a large animal …

I Inci, S Arni, I Iskender, N Citak, JM Rodriguez… - Cells, 2020 - mdpi.com
Background: Ex vivo lung perfusion (EVLP) is a technology that allows the re-evaluation of
questionable donor lung before implantation and it has the potential to repair injured donor …

Dodecafluoropentane emulsion as an oxygen therapeutic

JLH Johnson, E Unger - Artificial Cells, Nanomedicine, and …, 2024 - Taylor & Francis
Dodecafluoropentane emulsion (DDFPe) is a fluorocarbon (FC) under clinical development
as an oxygen therapeutic and is regulated as a blood substitute. Compared to all the prior …

Traumatic brain injury—a review of intravenous fluid therapy

A Pigott, E Rudloff - Frontiers in Veterinary Science, 2021 - frontiersin.org
Frontiers | Traumatic Brain Injury—A Review of Intravenous Fluid Therapy Skip to main
content Download Article Download Article Download PDF ReadCube EPUB XML (NLM) …

[HTML][HTML] Targeting the organelle for radiosensitization in cancer radiotherapy

X Sun, L Wu, L Du, W Xu, M Han - Asian Journal of Pharmaceutical …, 2024 - Elsevier
Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-
energy ionizing radiation to destroy cancer cells. However, this method has several …

Perfluorocarbons cause thrombocytopenia, changes in RBC morphology and death in a baboon model of systemic inflammation

HF Pidcoke, W Delacruz, MC Herzig, BS Schaffer… - Plos one, 2022 - journals.plos.org
A perfluorocarbon (PFC) investigated for treatment of traumatic brain injury (TBI) delivers
oxygen to support brain function, but causes transient thrombocytopenia. TBI can cause …

Cerebral microvascular and systemic effects following intravenous administration of the perfluorocarbon emulsion Perftoran

R Abutarboush, BK Saha, SH Mullah… - Journal of Functional …, 2016 - mdpi.com
Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue
oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of …

Dodecafluoropentane emulsion (DDFPE) as a resuscitation fluid for treatment of hemorrhagic shock and traumatic brain injury: a review

K Graham, PF Moon-Massat, EC Unger - Shock, 2019 - journals.lww.com
Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with
therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe …