Protein thermostability can be increased by some glycine to proline mutations in a target
protein. However, not all glycine to proline mutations can improve protein thermostability …

Dinâmica Molecular (DM) é uma ferramenta computacional poderosa usada em Química
Medicinal para o planejamento racional de fármacos. DM é uma extensão da Mecânica …

Nattokinase (NK) is a serine protease of the subtilisin family; as a potent fibrinolytic enzyme,
it is potentially useful for thrombosis therapy. For NK to be applied as an oral medicine for …

Amidase and laccase play a key role in the degradation process of anionic polyacrylamide
(HPAM). However, the largest challenge of HPAM enzymatic degradation is whether the …

Besides the catalytic ability, many enzymes contain conserved domains to perform some
other physiological functions. However, sometimes these conserved domains were …

Spontaneous mutations at numerous sites distant from the active site of human
immunodeficiency virus type 1 protease enable resistance to inhibitors while retaining …

Nitrile hydratase (NHase, EC 4.2. 1.84) is an excellent biocatalyst that catalyzes the
hydration of nitrile substances to their corresponding amides. Given its catalytic specificity …

Protein denaturation plays a crucial role in cellular processes. In this study, denaturation of
HIV-1 Protease (PR) was investigated by all-atom MD simulations in explicit solvent. The PR …

Evolution has lead proteins to display funneled energy landscapes with small degrees of
ruggedness. However, a funneled landscape does not preclude the presence of multiple …

Biochemical experiments have recently revealed that the p-S8 peptide, with an amino-acid
sequence identical to the conserved fragment 83–93 (S8) of the HIV-1 protease, can inhibit …