Cellular senescence is a key component of human aging that can be induced by a range of
stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of …

The recent clinical success of targeted therapies in melanoma directed at the oncogene
BRAF validates the concept of targeting oncogenes. The p16-cyclin D-CDK4/6 …

Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a
distinct gene expression profile, which is often accompanied by the spatial redistribution of …

Cellular senescence acts as a barrier to cancer progression, and microRNAs (miRNAs) are
thought to be potential senescence regulators. However, whether senescence-associated …

Polycomb group (PcG) proteins such as Enhancer of zeste homolog 2 (EZH2) are epigenetic
transcriptional repressors that function through recognition and modification of histone …

Radiation damage to biological systems is determined by the type of radiation, the total
dosage of exposure, the dose rate, and the region of the body exposed. Three modes of cell …

The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation.
Ras is a key molecule that controls several tumorigenesis-related processes, and mutations …

NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins
and platelet-derived growth factor receptor, that are essential for intercellular …

Persistent DNA damage is considered as a main cause of cellular senescence induced by
ionizing radiation. However, the molecular bases of the DNA damage and their contribution …

Inositol polyphosphate 5-phosphatases can terminate downstream signalling of
phosphatidylinositol-3 kinase; however, their biological role in the pathogenesis of cancer is …