[HTML][HTML] An updated review of lysophosphatidylcholine metabolism in human diseases

SH Law, ML Chan, GK Marathe, F Parveen… - International journal of …, 2019 - mdpi.com
Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

The mechanisms of lysophosphatidylcholine in the development of diseases

P Liu, W Zhu, C Chen, B Yan, L Zhu, X Chen, C Peng - Life sciences, 2020 - Elsevier
Lysophosphatidylcholine (LPC) is the main component of oxidatively damaged low-density
lipoprotein (oxLDL). LPC originates from the cleavage of phosphatidylcholine by …

How macrophages deal with death

G Lemke - Nature Reviews Immunology, 2019 - nature.com
Tissue macrophages rapidly recognize and engulf apoptotic cells. These events require the
display of so-called eat-me signals on the apoptotic cell surface, the most fundamental of …

[HTML][HTML] In vitro cell migration and invasion assays

CR Justus, N Leffler, M Ruiz-Echevarria… - Journal of visualized …, 2014 - ncbi.nlm.nih.gov
Migration is a key property of live cells and critical for normal development, immune
response, and disease processes such as cancer metastasis and inflammation. Methods to …

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

P Chen, H Zuo, H Xiong, MJ Kolar… - Proceedings of the …, 2017 - National Acad Sciences
Macrophages are prominent immune cells in the tumor microenvironment that exert potent
effects on cancer metastasis. However, the signals and receivers for the tumor–macrophage …

[HTML][HTML] Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum

NMB Brancucci, JP Gerdt, CQ Wang, M De Niz… - Cell, 2017 - cell.com
Transmission represents a population bottleneck in the Plasmodium life cycle and a key
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential …

Macrophage‐mediated tumor cell phagocytosis: opportunity for nanomedicine intervention

X Zhou, X Liu, L Huang - Advanced functional materials, 2021 - Wiley Online Library
Macrophages are one of the most abundant non‐malignant cells in the tumor
microenvironment, playing critical roles in mediating tumor immunity. As important innate …

[HTML][HTML] Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

CR Justus, L Dong, LV Yang - Frontiers in physiology, 2013 - frontiersin.org
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and
deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an …

Mammalian G proteins and their cell type specific functions

N Wettschureck, S Offermanns - Physiological reviews, 2005 - journals.physiology.org
Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

The sponge microbiome project

L Moitinho-Silva, S Nielsen, A Amir, A Gonzalez… - …, 2017 - academic.oup.com
Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in
southwest China covers several different habitats and environments. However, not much …