Accurate and complete genome duplication is crucial to maintain cell survival and prevent
malignant transformation. The Fanconi anemia (FA) pathway has traditionally been …

Non-homologous end-joining (NHEJ) is the preferred mechanism used by hematopoietic
stem cells (HSCs) to repair double-stranded DNA breaks and is particularly increased in …

Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand
breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous …

The cross talk between extrinsic niche-derived and intrinsic hematopoietic stem cell (HSC)
factors controlling HSC maintenance remains elusive. Here, we demonstrated that …

The potential genotoxic effects of engineered nanomaterials (ENMs) may occur through the
induction of DNA damage or the disruption of DNA repair processes. Inefficient DNA repair …

Programmable nucleases have enabled rapid and accessible genome engineering in
eukaryotic cells and living organisms. However, their delivery into human blood cells can be …

Abstract The transcriptional repressor Hairy Enhancer of Split 1 (HES1) plays an essential
role in the development of many organs by promoting the maintenance of stem/progenitor …

Fanconi anaemia (FA) is a hereditary disorder characterized by bone marrow failure,
developmental defects, predisposition to cancer and chromosomal abnormalities. FA is …

Defects in genes involved in DNA damage repair (DDR) pathway are emerging as novel
biomarkers and targets for new prostate cancer drug therapies. A previous report revealed …

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy caused by
somatically acquired changes affecting a well-defined set of genes 1. While rare high-risk …