Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction
Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two …
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two …
Neuroinflammation in primary open-angle glaucoma
S Vernazza, S Tirendi, AM Bassi, CE Traverso… - Journal of clinical …, 2020 - mdpi.com
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …
worldwide. Increasing evidence suggests oxidative damage and immune response defects …
Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma
Increased flow resistance is responsible for the elevated intraocular pressure characteristic
of glaucoma, but the cause of this resistance increase is not known. We tested the …
of glaucoma, but the cause of this resistance increase is not known. We tested the …
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA
Primary open-angle glaucoma (POAG) is a genetically complex common disease
characterized by progressive optic nerve degeneration that results in irreversible blindness …
characterized by progressive optic nerve degeneration that results in irreversible blindness …
The outflow pathway: a tissue with morphological and functional unity
SC Saccà, S Gandolfi, A Bagnis… - Journal of cellular …, 2016 - Wiley Online Library
The trabecular meshwork (TM) plays an important role in high‐tension glaucomas. Indeed,
the TM is a true organ, through which the aqueous humor flows from the anterior chamber to …
the TM is a true organ, through which the aqueous humor flows from the anterior chamber to …
Adenosine, adenosine receptors and glaucoma: an updated overview
Y Zhong, Z Yang, WC Huang, X Luo - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
BACKGROUND: Glaucoma, a leading cause of blindness worldwide, is an optic neuropathy
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …
Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow
Primary open-angle glaucoma is associated with elevated intraocular pressure, which in
turn is believed to result from impaired outflow of aqueous humour. Aqueous humour outflow …
turn is believed to result from impaired outflow of aqueous humour. Aqueous humour outflow …
Improving stem cell delivery to the trabecular meshwork using magnetic nanoparticles
Glaucoma is a major cause of blindness and is frequently associated with elevated
intraocular pressure. The trabecular meshwork (TM), the tissue that primarily regulates …
intraocular pressure. The trabecular meshwork (TM), the tissue that primarily regulates …
Implementing new computational methods for the study of JCT and SC inner wall basement membrane biomechanics and hydrodynamics
Purpose The conventional aqueous outflow pathway, which includes the trabecular
meshwork (TM), juxtacanalicular tissue (JCT), and the inner wall endothelium of Schlemm's …
meshwork (TM), juxtacanalicular tissue (JCT), and the inner wall endothelium of Schlemm's …
Differential effects of trabecular meshwork stiffness on outflow facility in normal human and porcine eyes
LJ Camras, WD Stamer, D Epstein… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: The study was designed to determine trabecular meshwork (TM) stiffness and its
relationship to outflow facility (C) in perfused normal human and porcine eyes. Methods …
relationship to outflow facility (C) in perfused normal human and porcine eyes. Methods …