The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

Alveolar epithelial cell (AEC) senescence is a key driver of a variety of chronic lung
diseases. It remains a challenge how to alleviate AEC senescence and mitigate disease …

DNA‐encoded chemical library technology was developed with the vision of its becoming a
transformational platform for drug discovery. The hope was that a new paradigm for the …

Cancer therapy, including immunotherapy, is inherently limited by chronic inflammation-
induced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the …

The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

Therapeutics for arachidonic acid pathways began with the development of non-steroidal
anti-inflammatory drugs that inhibit cyclooxygenase (COX). The enzymatic pathways and …

Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or
local pulmonary inflammation, such as caused by severe acute respiratory syndrome …

Epoxyeicosatrienoic acids (EETs) are also known as epoxyeicosanoids that have renal and
cardiovascular actions. These renal and cardiovascular actions can be regulated by soluble …

Abstract Background Epoxyeicosatrienoates (EETs) are endogenous regulators of
neuroinflammation and cerebral blood flow. Their metabolism to dihydroxyeicosatrienoates …