Topoisomerase II inhibitors design: Early studies and new perspectives
The DNA topoisomerase enzymes are widely distributed throughout all spheres of life and
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …
Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines
T Capelôa, Z Benyahia, LX Zampieri… - Seminars in cell & …, 2020 - Elsevier
Abstract Anthracyclines Doxorubicin, Epirubicin, Daunorubicin and Idarubicin are used to
treat a variety of tumor types in the clinics, either alone or, most often, in combination …
treat a variety of tumor types in the clinics, either alone or, most often, in combination …
[HTML][HTML] Effective breast cancer therapy based on palmitic acid-loaded PLGA nanoparticles
Y He, RF de Araújo Júnior, RS Cavalcante, Z Yu… - Biomaterials …, 2023 - Elsevier
Although new strategies for breast cancer treatment have yielded promising results, most
drugs can lead to serious side effects when applied systemically. Doxorubicin (DOX) …
drugs can lead to serious side effects when applied systemically. Doxorubicin (DOX) …
Doxorubicin-loaded biodegradable capsules: Temperature induced shrinking and study of cytotoxicity in vitro
DB Trushina, RA Akasov, AV Khovankina… - Journal of molecular …, 2019 - Elsevier
Doxorubicin (DOX) is one of mainstays in anticancer therapy due to its universal anticancer
activity. Development of DOX delivery systems is of particular importance aiming a reduction …
activity. Development of DOX delivery systems is of particular importance aiming a reduction …
Thiosemicarbazones can act synergistically with anthracyclines to downregulate CHEK1 expression and induce DNA damage in cell lines derived from pediatric solid …
S Paukovcekova, M Krchniakova, P Chlapek… - International Journal of …, 2022 - mdpi.com
Anticancer therapy by anthracyclines often leads to the development of multidrug resistance
(MDR), with subsequent treatment failure. Thiosemicarbazones have been previously …
(MDR), with subsequent treatment failure. Thiosemicarbazones have been previously …
[HTML][HTML] Doxorubicin and α-Mangostin oppositely affect luminal breast cancer cell stemness evaluated by a new retinaldehyde-dependent ALDH assay in MCF-7 …
I Bissoli, C Muscari - Biomedicine & Pharmacotherapy, 2020 - Elsevier
According to cancer stem cell theory, only a limited number of self-renewing and cloning
cells are responsible for tumor relapse after a period of remittance. The aim of the present …
cells are responsible for tumor relapse after a period of remittance. The aim of the present …
Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubicin
S Federico, A Martorana, G Pitarresi, FS Palumbo… - Biomaterials …, 2022 - Elsevier
In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have
been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by …
been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by …
An in vivo zebrafish model reveals circulating tumor cell targeting capacity of serum albumin nanoparticles
G Cakan-Akdogan, E Ersoz, SC Sozer… - Journal of Drug Delivery …, 2022 - Elsevier
Nanoparticles are promising tools of drug delivery in modern medicine. There is a need for
fast and reliable models for in vivo validation of newly developed nanocarriers. Here, we …
fast and reliable models for in vivo validation of newly developed nanocarriers. Here, we …
Development of two layer fibrous scaffolds for 3D in vitro modelling: Effects of morphology and surface properties on cell proliferation, adhesion and drug sensitivity
A Pupiute, D Ciuzas, O Baniukaitiene… - Journal of Drug Delivery …, 2024 - Elsevier
Abstract Three-dimensional (3D) in vitro cell models are gaining popularity in cancer
research compared to two-dimensional (2D) cell culture models because of their ability to …
research compared to two-dimensional (2D) cell culture models because of their ability to …
Computational study to select the capable anthracycline derivatives through an overview of drug structure-specificity and cancer cell line-specificity
A comprehensive study on anthracycline derivatives was done. A quantitative structure–
activity relationship (QSAR) study on the half-maximal inhibitory concentration (IC 50) of …
activity relationship (QSAR) study on the half-maximal inhibitory concentration (IC 50) of …