Genomic surveillance for antimicrobial resistance—a One Health perspective

SP Djordjevic, VM Jarocki, T Seemann… - Nature Reviews …, 2024 - nature.com
Antimicrobial resistance (AMR)—the ability of microorganisms to adapt and survive under
diverse chemical selection pressures—is influenced by complex interactions between …

Small-molecule antibiotic drug development: need and challenges

M Bergkessel, B Forte, IH Gilbert - ACS Infectious Diseases, 2023 - ACS Publications
The need for new antibiotics is urgent. Antimicrobial resistance is rising, although currently,
many more people die from drug-sensitive bacterial infections. The continued evolution of …

Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention

CL Holmes, OR Albin, HLT Mobley… - Nature Reviews …, 2024 - nature.com
Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing
in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune …

Modulation of multidrug-resistant clone success in Escherichia coli populations: a longitudinal, multi-country, genomic and antibiotic usage cohort study

AK Pöntinen, RA Gladstone, H Pesonen… - The Lancet …, 2024 - thelancet.com
Background The effect of antibiotic usage on the success of multidrug-resistant (MDR)
clones in a population remains unclear. With this genomics-based molecular epidemiology …

Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and …

D Li, P Elankumaran, T Kudinha… - Microbial …, 2023 - microbiologyresearch.org
Extraintestinal pathogenic Escherichia coli (ExPEC) are the most frequent cause of urinary
tract infections (UTIs) globally. Most studies of clinical E. coli isolates are selected based on …

Assessment of Prevalence and Diversity of Antimicrobial Resistant Escherichia coli from Retail Meats in Southern California

KY Lee, K Lavelle, A Huang, ER Atwill, M Pitesky, X Li - Antibiotics, 2023 - mdpi.com
Retail meat products may serve as reservoirs and conduits for antimicrobial resistance,
which is frequently monitored using Escherichia coli as indicator bacteria. In this study, E …

[HTML][HTML] Genomic epidemiology of multidrug-resistant Escherichia coli and Klebsiella pneumoniae in Kenya, Uganda, and Jordan

DK Byarugaba, TS Osman… - Emerging Infectious …, 2024 - pmc.ncbi.nlm.nih.gov
Surveillance of antimicrobial resistance in Kenya, Uganda, and Jordan identified multidrug-
resistant high-risk bacterial clones: Escherichia coli sequence types 131, 1193, 69, 167, 10 …

[HTML][HTML] Green synthesis, characterization and antimicrobial activity of iron oxide nanoparticles with tigecycline against multidrug resistant bacterial strains

MT Yassin, FO Al-Otibi, AA Al–Askar - Journal of King Saud University …, 2024 - Elsevier
Objectives The current study focused on the green synthesis of iron oxide nanoparticles
(IONPs) using Salvia officinalis leaf extract, aiming to control nosocomial infections caused …

Pan-pathogen deep sequencing of nosocomial bacterial pathogens in Italy in spring 2020: a prospective cohort study

HA Thorpe, M Pesonen, M Corbella, H Pesonen… - The Lancet …, 2024 - thelancet.com
Background Nosocomial infections pose a considerable risk to patients who are susceptible,
and this is particularly acute in intensive care units when hospital-associated bacteria are …

Temporal dynamics of genetically heterogeneous extended-spectrum cephalosporin-resistant Escherichia coli bloodstream infections

WC Shropshire, B Strope, S Selvaraj Anand, J Bremer… - Msphere, 2023 - Am Soc Microbiol
Extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R-Ec) is an urgent public
health threat with sequence type clonal complex 131 (STc131), phylogroup B2 strains being …