Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) in human disease, an overview

MF Lindberg, L Meijer - International Journal of Molecular Sciences, 2021 - mdpi.com
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells

IM Rezig, WG Yaduma, GW Gould, CJ McInerny - Cell Cycle, 2023 - Taylor & Francis
Cytokinesis is the final stage of cell division cycle when cellular constituents are separated
to produce two daughter cells. This process is driven by the formation and constriction of a …

DYRK-family kinases regulate Candida albicans morphogenesis and virulence through the Ras1/PKA pathway

J MacAlpine, Z Liu, S Hossain, L Whitesell, N Robbins… - MBio, 2023 - Am Soc Microbiol
Candida albicans is an opportunistic human fungal pathogen that causes common
superficial mycoses in healthy populations and invasive disease in immunocompromised …

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

R Bhattacharjee, AR Hall, MSC Mangione, MG Igarashi… - Elife, 2023 - elifesciences.org
Abstract The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces
pombe and plays a key role in attaching the cytokinetic ring (CR) to the plasma membrane …

Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis

JO Magliozzi, J Sears, L Cressey, M Brady… - Journal of Cell …, 2020 - rupress.org
Protein kinases direct polarized growth by regulating the cytoskeleton in time and space and
could play similar roles in cell division. We found that the Cdc42-activated polarity kinase …

[HTML][HTML] Opposite surfaces of the Cdc15 F-BAR domain create a membrane platform that coordinates cytoskeletal and signaling components for cytokinesis

CE Snider, M Chandra, NA McDonald, AH Willet… - Cell reports, 2020 - cell.com
Many eukaryotes assemble an actin-and myosin-based cytokinetic ring (CR) on the plasma
membrane (PM) for cell division, but how it is anchored there remains unclear. In …

Live-cell imaging defines a threshold in CDK activity at the G2/M transition

H Sugiyama, Y Goto, Y Kondo, D Coudreuse, K Aoki - Developmental Cell, 2024 - cell.com
Cyclin-dependent kinase (CDK) determines the temporal ordering of the cell cycle phases.
However, despite significant progress in studying regulators of CDK and phosphorylation …

Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring

CE Snider, R Bhattacharjee, MG Igarashi… - Molecular Biology of …, 2022 - Am Soc Cell Biol
The F-BAR protein Cdc15 mediates attachment of the cytokinetic ring (CR) to the plasma
membrane and is essential for cytokinesis in Schizosaccharomyces pombe. While its N …

Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment

AH Willet, MG Igarashi, JS Chen… - Journal of cell …, 2021 - journals.biologists.com
ABSTRACT The F-BAR protein Imp2 is an important contributor to cytokinesis in the fission
yeast Schizosaccharomyces pombe. Because cell cycle-regulated phosphorylation of the …

Processes Controlling the Contractile Ring during Cytokinesis in Fission Yeast, Including the Role of ESCRT Proteins

IM Rezig, WG Yaduma, CJ McInerny - Journal of Fungi, 2024 - mdpi.com
Cytokinesis, as the last stage of the cell division cycle, is a tightly controlled process
amongst all eukaryotes, with defective division leading to severe cellular consequences and …