Type 2 diabetes develops in the context of both insulin resistance and β-cell failure.
Thiazolidinediones are a class of antidiabetic agents that are known to improve insulin …

The pancreas is a complex organ with exocrine and endocrine components. Many
pathologies impair exocrine function, including chronic pancreatitis, cystic fibrosis and …

The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy
is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with …

Failure of insulin producing pancreatic β-cells is a common characteristic of type 1 (insulin-
dependent) and type 2 (insulin non-dependent) diabetes mellitus. Accumulating evidence …

Chronic hyperglycemia is toxic to pancreatic β-cells, impairing cellular functioning as
observed in type 2 diabetes; however, the mechanism underlying β-cell dysfunction and the …

Biochem., 61 (4), 529-538, 2005. GLUT2 is a facilitative glucose transporter located in the
plasma membrane of the liver, pancreatic, intestinal, kidney cells as well as in the portal and …

Thiazolidinediones, synthetic ligands of peroxisomal proliferator-activated receptor-γ (PPAR-
γ), improve peripheral insulin sensitivity and glucose-stimulated insulin secretion in …

Neutrophils are phagocytic cells of the innate immune system that use a combination of
reactive oxygen species and anti-microbial toxins to kill and destroy ingested micro …

We have examined the regulation of hepatic growth hormone receptors (GH-R) and serum
GH binding proteins (GHBP) in transgenic mice expressing an antagonist of bovine growth …

▪ Abstract The field of metabolic engineering encompasses a powerful set of tools that can
be divided into (a) methods to model complex metabolic pathways and (b) techniques to …