In 2018, there was a recent shift towards a biological definition of Alzheimer's disease (AD),
based on biomarkers measured in vivo even before the onset of clinical dementia …

Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …

Purpose Mild cognitive impairment (MCI) is a transitional pathological stage between normal
ageing (NA) and Alzheimer's disease (AD). Although subjects with MCI show a decline at …

Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …

Computerized clinical decision support systems can help to provide objective, standardized,
and timely dementia diagnosis. However, current computerized systems are mainly based …

Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly, affecting millions of people worldwide and clinically characterized by a progressive …

Background The clinical dementia rating (CDR) scale is commonly used to diagnose
dementia due to Alzheimer's disease (AD). The sum of boxes of the CDR (CDR-SB) has …

The neuroimaging method of multimodal magnetic resonance imaging (MRI) can identify the
changes in brain structure and function caused by Alzheimer's disease (AD) at different …

The differentiation of dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) using
brain perfusion single photon emission tomography is important but is challenging because …

Central nervous system (CNS) drug discovery suffers from high attrition rates; translational
neuroscience approaches aiming to reduce these high rates include the use of brain …